RESUMO
Tuberculosis is both a nosocomial and an occupational infection. The prevalence of positive tuberculin skin reactions at King Abdulaziz University Hospital, Saudi Arabia, was investigated by testing 298 health care workers. Conventional tuberculin skin testing was performed using 0.1 mL of purified protein derivative injected intracutaneously. After 48-72 hours, induration size was recorded. The prevalence of positive tests (induration > or = 10 mm) was 78.9% overall, 60.0% for Saudi Arabians compared with 81.8% for non-Saudi Arabians (P < 0.01). The mean response size (8.9 +/- 7 mm) for Saudis was also significantly lower than for non-Saudis (13.9 +/- 7 mm, P < 0.001). To enhance the protection of both health care workers and hospitalized patients, effective preventive measures and annual tuberculin testing of health care workers should be considered.
Assuntos
Hospitais Universitários , Doenças Profissionais , Recursos Humanos em Hospital/estatística & dados numéricos , Teste Tuberculínico , Tuberculose , Vacina BCG , Distribuição de Qui-Quadrado , Reações Falso-Negativas , Reações Falso-Positivas , Humanos , Incidência , Controle de Infecções , Programas de Rastreamento/métodos , Programas de Rastreamento/normas , Doenças Profissionais/diagnóstico , Doenças Profissionais/epidemiologia , Doenças Profissionais/prevenção & controle , Saúde Ocupacional/estatística & dados numéricos , Guias de Prática Clínica como Assunto , Prevalência , Características de Residência/estatística & dados numéricos , Medição de Risco , Fatores de Risco , Arábia Saudita/epidemiologia , Fatores Socioeconômicos , Fatores de Tempo , Tuberculina , Teste Tuberculínico/métodos , Tuberculose/diagnóstico , Tuberculose/epidemiologia , Tuberculose/prevenção & controleRESUMO
Tuberculosis is both a nosocomial and an occupational infection. The prevalence of positive tuberculin skin reactions at King Abdulaziz University Hospital, Saudi Arabia, was investigated by testing 298 health care workers. Conventional tuberculin skin testing was performed using 0.1 mL of purified protein derivative injected intracutaneously. After 48-72 hours, induration size was recorded. The prevalence of positive tests [induration > / = 10 mm] was 78.9% overall, 60.0% for Saudi Arabians compared with 81.8% for non-Saudi Arabians [P < 0.01]. The mean response size [8.9 +/- 7 mm] for Saudis was also significantly lower than for non-Saudis [13.9 +/- 7 mm, P < 0.001]. To enhance the protection of both health care workers and hospitalized patients, effective preventive measures and annual tuberculin testing of health care workers should be considered
Assuntos
Vacina BCG , Reações Falso-Negativas , Reações Falso-Positivas , Hospitais Universitários , Controle de Infecções , Programas de Rastreamento , Recursos Humanos em Hospital , Fatores de Risco , Tuberculina , Teste Tuberculínico , TuberculoseAssuntos
Anafilaxia/etiologia , Hipersensibilidade a Drogas/diagnóstico , Penicilina G/efeitos adversos , Penicilinas/efeitos adversos , Testes Cutâneos/efeitos adversos , Adulto , Anafilaxia/prevenção & controle , Celulite (Flegmão)/tratamento farmacológico , Epinefrina/uso terapêutico , Evolução Fatal , Feminino , Humanos , Injeções Intradérmicas , Testes Cutâneos/métodos , Testes Cutâneos/normas , Vasoconstritores/uso terapêuticoRESUMO
BACKGROUND: Discrepancy in asthmatic assessment by symptoms and peak flow rate (PFR) is a frequent dilemma. Currently, total peripheral eosinophil count (TPEC) is under study for asthma evaluation. OBJECTIVES: To explore the correlation between TPEC and asthma severity assessed by symptoms alone versus symptoms and PFR. METHOD: Adults asthmatics were selected from the Asthma Clinic. Severity assessment was based on two methods: symptoms alone or symptoms and PFR. Expiratory PFR was recorded by a Wright peak flow meter. Severity levels included mild intermittent, mild persistent, moderate persistent, and severe persistent. Total peripheral eosinophil count was performed on a Celldyn-3500 counter. Data was analyzed for statistical significance. RESULTS: Sixty asthmatics aged 15 to 70 years (mean = 34 years), of which 68.3% were female, were studied. Severity levels differed between the two assessment methods in 45% of the cases and showed a predominance of the moderate persistent type. Total peripheral eosinophil count ranged between 22 and 2470 cells/mm3 (mean = 520 +/- SD = 393) and eosinophilia was found in 50% of the cases. Total peripheral eosinophil count showed a high positive correlation with increased asthma severity level assessed by history alone (r = 0.460, P < .001); more than by history and PFR (r = 0.328, P < .05). CONCLUSION: The discrepancy between symptoms and PFR is confirmed by these results. A reliable objective parameter in asthma assessment is a continuous challenge. This study advocates the possible supplementation of TPEC as another objective parameter that might help in selecting the appropriate severity level in asthmatics.
Assuntos
Asma/fisiopatologia , Eosinófilos/citologia , Contagem de Leucócitos , Pico do Fluxo Expiratório , Adolescente , Adulto , Idoso , Asma/sangue , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Estudos Prospectivos , Índice de Gravidade de DoençaRESUMO
Full text is available as a scanned copy of the original print version.
RESUMO
Full text is available as a scanned copy of the original print version.